Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation

BACKGROUND: Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance. We previously showed that G6PD inhibition leads to Endoplasmic Reticulum (ER) stress often associated to autophagy deregulation. The...

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Detalles Bibliográficos
Autores principales: Mele, Luigi, la Noce, Marcella, Paino, Francesca, Regad, Tarik, Wagner, Sarah, Liccardo, Davide, Papaccio, Gianpaolo, Lombardi, Angela, Caraglia, Michele, Tirino, Virginia, Desiderio, Vincenzo, Papaccio, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466760/
https://www.ncbi.nlm.nih.gov/pubmed/30987650
http://dx.doi.org/10.1186/s13046-019-1164-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466760/
https://www.ncbi.nlm.nih.gov/pubmed/30987650
http://dx.doi.org/10.1186/s13046-019-1164-5

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