CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling

CRISPR/Cas9 has revolutionized cancer mouse models. Although loss-of-function genetics by CRISPR/Cas9 is well-established, generating gain-of-function alleles in somatic cancer models is still challenging because of the low efficiency of gene knock-in. Here we developed CRISPR-based Somatic Oncogene...

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Detalles Bibliográficos
Autores principales: Mou, Haiwei, Ozata, Deniz M., Smith, Jordan L., Sheel, Ankur, Kwan, Suet-Yan, Hough, Soren, Kucukural, Alper, Kennedy, Zachary, Cao, Yueying, Xue, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466773/
https://www.ncbi.nlm.nih.gov/pubmed/30987660
http://dx.doi.org/10.1186/s13073-019-0627-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466773/
https://www.ncbi.nlm.nih.gov/pubmed/30987660
http://dx.doi.org/10.1186/s13073-019-0627-9

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