Cargando…

Autophagy mediates serum starvation-induced quiescence in nucleus pulposus stem cells by the regulation of P27

BACKGROUND: Adult stem cells exist in a quiescent state (G0) within the in vivo niche; the loss of quiescence often leads to a decrease in the number and function of adult stem cells, impairing tissue regeneration and repair. Endogenous repair by nucleus pulposus-derived stem cells has recently show...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Bin, Sun, Chao, Sun, Jing, Yang, Ming-hui, Zuo, Rui, Liu, Chang, Lan, Wei-ren, Liu, Ming-han, Huang, Bo, Zhou, Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466800/ https://www.ncbi.nlm.nih.gov/pubmed/30987681 http://dx.doi.org/10.1186/s13287-019-1219-8

Ejemplares similares

Inhibition of the Notch1 Pathway Promotes the Effects of Nucleus Pulposus Cell-Derived Exosomes on the Differentiation of Mesenchymal Stem Cells into Nucleus Pulposus-Like Cells in Rats
por: Lan, Wei-ren, et al.
Publicado: (2019)

Hydrogen sulfide regulates autophagy in nucleus pulposus cells under hypoxia
por: Yue, Lei, et al.
Publicado: (2021)

Autophagy is required for G(1)/G(0) quiescence in response to nitrogen starvation in Saccharomyces cerevisiae
por: An, Zhenyi, et al.
Publicado: (2014)

Hypoxia Helps Maintain Nucleus Pulposus Homeostasis by Balancing Autophagy and Apoptosis
por: Kim, Han-Jun, et al.
Publicado: (2020)

Quiescence preconditioned nucleus pulposus stem cells alleviate intervertebral disc degeneration by enhancing cell survival via adaptive metabolism pattern in rats
por: Chen, Qi, et al.
Publicado: (2023)

Impact of NF-κB pathway on the apoptosis-inflammation-autophagy crosstalk in human degenerative nucleus pulposus cells
por: Yi, Weiwei, et al.
Publicado: (2019)

Lack of evidence for involvement of TonEBP and hyperosmotic stimulus in induction of autophagy in the nucleus pulposus
por: Liu, Chao, et al.
Publicado: (2017)

Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy
por: Luo, Liwen, et al.
Publicado: (2021)

Parallel proteomics and phosphoproteomics defines starvation signal specific processes in cell quiescence
por: Sun, Siyu, et al.
Publicado: (2023)

Mechanism of Long Noncoding RNA HOTAIR in Nucleus Pulposus Cell Autophagy and Apoptosis in Intervertebral Disc Degeneration
por: Zhang, Shujun, et al.
Publicado: (2022)

Relationships Between Disc Degeneration and Autophagy Expression in Human Nucleus Pulposus
por: Quan, Meiling, et al.
Publicado: (2019)

Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence
por: Li, Xiao-Chuan, et al.
Publicado: (2018)

TNFAIP3 ameliorates the degeneration of inflammatory human nucleus pulposus cells by inhibiting mTOR signaling and promoting autophagy
por: Chen, Jie, et al.
Publicado: (2020)

Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells
por: Lian, Chengjie, et al.
Publicado: (2017)

Inducing Angiogenesis in the Nucleus Pulposus
por: Damle, Sheela R., et al.
Publicado: (2023)

MiR-27a Regulates Apoptosis in Nucleus Pulposus Cells by Targeting PI3K
por: Liu, Gang, et al.
Publicado: (2013)

Expression and effects of leukemia inhibitory factor on nucleus pulposus degeneration
por: Xiao, Qiang, et al.
Publicado: (2019)

SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells
por: Jiang, Wei, et al.
Publicado: (2014)

BRD4 Inhibition Suppresses Senescence and Apoptosis of Nucleus Pulposus Cells by Inducing Autophagy during Intervertebral Disc Degeneration: An In Vitro and In Vivo Study
por: Zhang, Guang-Zhi, et al.
Publicado: (2022)

Expansion of FGFR3-positive nucleus pulposus cells plays important roles in postnatal nucleus pulposus growth and regeneration
por: Xu, Meng, et al.
Publicado: (2022)

Construction of tissue-engineered nucleus pulposus by stimulation with periodic mechanical stress and BMP-2
por: Liu, Yang, et al.
Publicado: (2022)

High Glucose Induces Autophagy through PPARγ-Dependent Pathway in Human Nucleus Pulposus Cells
por: Jiang, Chang, et al.
Publicado: (2018)

Autophagy mediates glucose starvation-induced glioblastoma cell quiescence and chemoresistance through coordinating cell metabolism, cell cycle, and survival
por: Wang, Lian, et al.
Publicado: (2018)

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration
por: Zhang, Guang‐Zhi, et al.
Publicado: (2021)

Survivin is expressed in degenerated nucleus pulposus cells and is involved in proliferation and the prevention of apoptosis in vitro
por: LIN, YAZHOU, et al.
Publicado: (2016)

Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes
por: Luo, Liwen, et al.
Publicado: (2021)

6-gingerol protects nucleus pulposus-derived mesenchymal stem cells from oxidative injury by activating autophagy
por: Nan, Li-Ping, et al.
Publicado: (2020)

Current Perspectives on Nucleus Pulposus Fibrosis in Disc Degeneration and Repair
por: Sun, Yi, et al.
Publicado: (2022)

Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells
por: Xie, Chenglong, et al.
Publicado: (2022)

Raloxifene retards the progression of adjacent segmental intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus in ovariectomized rats
por: Sun, Qi, et al.
Publicado: (2021)

IL-1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells
por: Shen, Jieliang, et al.
Publicado: (2017)

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration
por: Chen, Hai-Wei, et al.
Publicado: (2021)

miR-573 regulates cell proliferation and apoptosis by targeting Bax in nucleus pulposus cells
por: Wang, Rui, et al.
Publicado: (2019)

The enigma that is the nucleus pulposus cell: the search goes on
por: Erwin, W Mark
Publicado: (2010)

Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration
por: Krouwels, Anita, et al.
Publicado: (2020)

Cell sources proposed for nucleus pulposus regeneration
por: Williams, Rebecca J., et al.
Publicado: (2021)

Alterations of bovine nucleus pulposus cells with aging
por: Molinos, Maria, et al.
Publicado: (2023)

Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration
por: Richardson, Stephen M., et al.
Publicado: (2017)

Protective effects of resveratrol on autologous nucleus pulposus model of radiculopathy
por: Lin, Bin, et al.
Publicado: (2016)

Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration
por: Zheng, Zengming, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_c4fbin70ck3kiee6isftd1ibcf