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A RADAR-Based Assay to Isolate Covalent DNA Complexes in Bacteria
Quinolone antibacterials target the type II topoisomerases gyrase and topoisomerase IV and kill bacterial cells by converting these essential enzymes into cellular poisons. Although much is known regarding the interactions between these drugs and enzymes in purified systems, much less is known regar...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466838/ https://www.ncbi.nlm.nih.gov/pubmed/30818799 http://dx.doi.org/10.3390/antibiotics8010017 |