High-resolution crystal structures of ribosome-bound chloramphenicol and erythromycin provide the ultimate basis for their competition

The 70S ribosome is a major target for antibacterial drugs. Two of the classical antibiotics, chloramphenicol (CHL) and erythromycin (ERY), competitively bind to adjacent but separate sites on the bacterial ribosome: the catalytic peptidyl transferase center (PTC) and the nascent polypeptide exit tu...

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Detalles Bibliográficos
Autores principales: Svetlov, Maxim S., Plessa, Elena, Chen, Chih-Wei, Bougas, Anthony, Krokidis, Marios G., Dinos, George P., Polikanov, Yury S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467010/
https://www.ncbi.nlm.nih.gov/pubmed/30733327
http://dx.doi.org/10.1261/rna.069260.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467010/
https://www.ncbi.nlm.nih.gov/pubmed/30733327
http://dx.doi.org/10.1261/rna.069260.118

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