tRNA deamination by ADAT requires substrate-specific recognition mechanisms and can be inhibited by tRFs

Adenosine deaminase acting on transfer RNA (ADAT) is an essential eukaryotic enzyme that catalyzes the deamination of adenosine to inosine at the first position of tRNA anticodons. Mammalian ADATs modify eight different tRNAs, having increased their substrate range from a bacterial ancestor that lik...

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Detalles Bibliográficos
Autores principales: Roura Frigolé, Helena, Camacho, Noelia, Castellví Coma, Maria, Fernández-Lozano, Carla, García-Lema, Jorge, Rafels-Ybern, Àlbert, Canals, Albert, Coll, Miquel, Ribas de Pouplana, Lluís
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467012/
https://www.ncbi.nlm.nih.gov/pubmed/30737359
http://dx.doi.org/10.1261/rna.068189.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467012/
https://www.ncbi.nlm.nih.gov/pubmed/30737359
http://dx.doi.org/10.1261/rna.068189.118

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