mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors

The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks m...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Ping Jun, Chen, Chien-Ju, Mays, Jacqunae, Stoica, Loredana, Costa-Mattioli, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467217/
https://www.ncbi.nlm.nih.gov/pubmed/29786082
http://dx.doi.org/10.1038/s41593-018-0156-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467217/
https://www.ncbi.nlm.nih.gov/pubmed/29786082
http://dx.doi.org/10.1038/s41593-018-0156-7

Ejemplares similares