mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors

The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks m...

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Autores principales: Zhu, Ping Jun, Chen, Chien-Ju, Mays, Jacqunae, Stoica, Loredana, Costa-Mattioli, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467217/
https://www.ncbi.nlm.nih.gov/pubmed/29786082
http://dx.doi.org/10.1038/s41593-018-0156-7
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author Zhu, Ping Jun
Chen, Chien-Ju
Mays, Jacqunae
Stoica, Loredana
Costa-Mattioli, Mauro
author_facet Zhu, Ping Jun
Chen, Chien-Ju
Mays, Jacqunae
Stoica, Loredana
Costa-Mattioli, Mauro
author_sort Zhu, Ping Jun
collection PubMed
description The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks mGluR-LTD in mTORC1-deficient mice. Interestingly, both rapamycin and mGluR activation regulate mTOR complex 2 (mTORC2) activity, and mTORC2-deficient mice show impaired mGluR-LTD and associated behaviors. Thus, mTORC2 is a major regulator of mGluR-LTD.
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spelling pubmed-64672172019-04-16 mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors Zhu, Ping Jun Chen, Chien-Ju Mays, Jacqunae Stoica, Loredana Costa-Mattioli, Mauro Nat Neurosci Article The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks mGluR-LTD in mTORC1-deficient mice. Interestingly, both rapamycin and mGluR activation regulate mTOR complex 2 (mTORC2) activity, and mTORC2-deficient mice show impaired mGluR-LTD and associated behaviors. Thus, mTORC2 is a major regulator of mGluR-LTD. 2018-05-21 2018-06 /pmc/articles/PMC6467217/ /pubmed/29786082 http://dx.doi.org/10.1038/s41593-018-0156-7 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Zhu, Ping Jun
Chen, Chien-Ju
Mays, Jacqunae
Stoica, Loredana
Costa-Mattioli, Mauro
mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
title mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
title_full mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
title_fullStr mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
title_full_unstemmed mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
title_short mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
title_sort mtorc2, but not mtorc1, is required for hippocampal mglur-ltd and associated behaviors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467217/
https://www.ncbi.nlm.nih.gov/pubmed/29786082
http://dx.doi.org/10.1038/s41593-018-0156-7
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