3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel

Bedaquiline is a new drug of the diarylquinoline class that has proven to be clinically effective against drug-resistant tuberculosis, but has a cardiac liability (prolongation of the QT interval) due to its potent inhibition of the cardiac potassium channel protein hERG. Bedaquiline is highly lipop...

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Detalles Bibliográficos
Autores principales: Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Blaser, Adrian, Conole, Daniel, Franzblau, Scott G., Lotlikar, Manisha U., Cooper, Christopher B., Upton, Anna M., Denny, William A., Palmer, Brian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467547/
https://www.ncbi.nlm.nih.gov/pubmed/30803745
http://dx.doi.org/10.1016/j.bmc.2019.02.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467547/
https://www.ncbi.nlm.nih.gov/pubmed/30803745
http://dx.doi.org/10.1016/j.bmc.2019.02.026

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