Human C5-specific single-chain variable fragment ameliorates brain injury in a model of NMOSD

OBJECTIVE: Using phage display, we sought to screen single-chain variable fragments (scFvs) against complement C5 to treat neuromyelitis optica spectrum disorder (NMOSD). METHODS: After 5 rounds of phage display, we isolated individual clones and identified phage clones specifically binding to C5 us...

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Detalles Bibliográficos
Autores principales: Zhu, Wenli, Wang, Zhen, Hu, Suying, Gong, Ye, Liu, Yuanchu, Song, Huanhuan, Ding, Xiaoli, Fu, Ying, Yan, Yaping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467685/
https://www.ncbi.nlm.nih.gov/pubmed/31044149
http://dx.doi.org/10.1212/NXI.0000000000000561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467685/
https://www.ncbi.nlm.nih.gov/pubmed/31044149
http://dx.doi.org/10.1212/NXI.0000000000000561

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