An experimentally validated approach to calculate the blood-brain barrier permeability of small molecules

Drug development for the treatment of central nervous system (CNS) diseases is extremely challenging, in large part due to the difficulty in crossing the blood-brain barrier (BBB). Here we develop and experimentally validate a new in silico method to predict quantitatively the BBB permeability for s...

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Detalles Bibliográficos
Autores principales: Wang, Yukun, Gallagher, Erin, Jorgensen, Christian, Troendle, Evan P., Hu, Dan, Searson, Peter C., Ulmschneider, Martin. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467875/
https://www.ncbi.nlm.nih.gov/pubmed/30992465
http://dx.doi.org/10.1038/s41598-019-42272-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467875/
https://www.ncbi.nlm.nih.gov/pubmed/30992465
http://dx.doi.org/10.1038/s41598-019-42272-0

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