p27/Kip1 functions as a tumor suppressor and oncoprotein in osteosarcoma

The p27/kip1 (p27) tumor suppressor inhibits cyclin/cyclin-dependent kinase (CDK) complexes and halts cell cycle progression. p27 further regulates invasion and migration in cancer cells, suggesting p27 also functions as an oncoprotein. Using a human osteosarcoma tissue microarray we identified high...

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Detalles Bibliográficos
Autores principales: Currier, Arthur W., Kolb, E. A., Gorlick, Richard G., Roth, Michael E., Gopalakrishnan, Vidya, Sampson, Valerie B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467888/
https://www.ncbi.nlm.nih.gov/pubmed/30992462
http://dx.doi.org/10.1038/s41598-019-42450-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467888/
https://www.ncbi.nlm.nih.gov/pubmed/30992462
http://dx.doi.org/10.1038/s41598-019-42450-0

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