Cargando…

p27/Kip1 functions as a tumor suppressor and oncoprotein in osteosarcoma

The p27/kip1 (p27) tumor suppressor inhibits cyclin/cyclin-dependent kinase (CDK) complexes and halts cell cycle progression. p27 further regulates invasion and migration in cancer cells, suggesting p27 also functions as an oncoprotein. Using a human osteosarcoma tissue microarray we identified high...

Descripción completa

Detalles Bibliográficos
Autores principales:	Currier, Arthur W., Kolb, E. A., Gorlick, Richard G., Roth, Michael E., Gopalakrishnan, Vidya, Sampson, Valerie B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467888/ https://www.ncbi.nlm.nih.gov/pubmed/30992462 http://dx.doi.org/10.1038/s41598-019-42450-0

Ejemplares similares

A Review of Targeted Therapies Evaluated by the Pediatric Preclinical Testing Program for Osteosarcoma
por: Sampson, Valerie B., et al.
Publicado: (2013)

Terminal osteoblast differentiation, mediated by runx2 and p27(KIP1), is disrupted in osteosarcoma
por: Thomas, David M., et al.
Publicado: (2004)

p27(kip1): a target for tumor therapies?
por: Nickeleit, Irina, et al.
Publicado: (2007)

Regulation of p27(Kip1) and p57(Kip2) Functions by Natural Polyphenols
por: Russo, Gian Luigi, et al.
Publicado: (2020)

p27(Kip1) and Ser10-phosphorylated p27(Kip1) in breast cancer: clinical significance and expression
por: Song, Wei, et al.
Publicado: (2015)

TMIGD1 acts as a tumor suppressor through regulation of p21Cip1/p27Kip1 in renal cancer
por: Meyer, Rosana D., et al.
Publicado: (2017)

lncRNA HCG11 suppresses human osteosarcoma growth through upregulating p27 Kip1
por: Gu, Jie, et al.
Publicado: (2021)

p27(Kip1) regulates alpha-synuclein expression
por: Gallastegui, Edurne, et al.
Publicado: (2018)

Role of p27(Kip1) as a transcriptional regulator
por: Bachs, Oriol, et al.
Publicado: (2018)

p27(KIP1) and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice
por: Shao, Jingchen, et al.
Publicado: (2016)

Structural prediction of the interaction of the tumor suppressor p27(KIP1) with cyclin A/CDK2 identifies a novel catalytically relevant determinant
por: Li, Jinyu, et al.
Publicado: (2017)

Discovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1)
por: Iconaru, Luigi I., et al.
Publicado: (2015)

p27(Kip1) – p(RhoB)lematic in lung cancer
por: Podmirseg, Silvio R, et al.
Publicado: (2019)

Immunohistochemical Expression of p27(Kip1), p57(Kip2), Cyclin D1, Nestin, and Ki-67 in Ependymoma
por: Iqneibi, Shahad, et al.
Publicado: (2022)

p27kip1 at the crossroad between actin and microtubule dynamics
por: Rampioni Vinciguerra, Gian Luca, et al.
Publicado: (2019)

p27(Kip1), an Intrinsically Unstructured Protein with Scaffold Properties
por: Bencivenga, Debora, et al.
Publicado: (2021)

p27(kip1) Modulates the Morphology and Phagocytic Activity of Microglia
por: Beeken, Jolien, et al.
Publicado: (2022)

Stat1 Phosphorylation Determines Ras Oncogenicity by Regulating p27(Kip1)
por: Wang, Shuo, et al.
Publicado: (2008)

Integrating mechanisms of response and resistance against the tubulin binding agent Eribulin in preclinical models of osteosarcoma
por: Sampson, Valerie B., et al.
Publicado: (2016)

ING Proteins: Tumour Suppressors or Oncoproteins
por: Jacquet, Karine, et al.
Publicado: (2021)

Prognostic role of p27(Kip1) and apoptosis in human breast cancer
por: Wu, J, et al.
Publicado: (1999)

Significance of p27(kip1) as potential biomarker for intracellular oxidative status
por: Quintos, Lesley, et al.
Publicado: (2010)

Akt/p27(kip1) Pathway Is Not Involved in Human Insulinoma Tumorigenesis
por: Díaz, Adriana Graciela, et al.
Publicado: (2018)

Immunohistochemical localization of mdm-2, p27(Kip1 )and bcl-2 in Warthin's tumor of the parotid gland
por: Abd-Elhamid, Ehab S, et al.
Publicado: (2009)

Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27(kip1)
por: Lloyd, Katie A., et al.
Publicado: (2016)

IL-7 promotes T cell proliferation through destabilization of p27(Kip1)
por: Li, Wen Qing, et al.
Publicado: (2006)

Expression of cyclin-dependent kinase inhibitor p27kip1 in malignant lymphomas.
por: Oh, Y. H., et al.
Publicado: (2000)

Role of T198 Modification in the Regulation of p27(Kip1) Protein Stability and Function
por: Schiappacassi, Monica, et al.
Publicado: (2011)

Nanog induces suppression of senescence through downregulation of p27(KIP1) expression
por: Münst, Bernhard, et al.
Publicado: (2016)

Genetic characterization of p27(kip1) and stathmin in controlling cell proliferation in vivo
por: Berton, Stefania, et al.
Publicado: (2014)

Cell type-specific effects of p27(KIP1) loss on retinal development
por: Ogawa, Mariko, et al.
Publicado: (2017)

Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6
por: Deshmukh, Dhanraj, et al.
Publicado: (2022)

CDKN1C/p57(kip2 )is a candidate tumor suppressor gene in human breast cancer
por: Larson, Pamela S, et al.
Publicado: (2008)

Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells
por: Rico-Bautista, Elizabeth, et al.
Publicado: (2010)

Effect of Xpcl1 Activation and p27(Kip1) Loss on Gene Expression in Murine Lymphoma
por: Kuppers, Daniel A., et al.
Publicado: (2011)

Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1)
por: Huang, J, et al.
Publicado: (2014)

CRM-1 knockdown inhibits extrahepatic cholangiocarcinoma tumor growth by blocking the nuclear export of p27(Kip1)
por: Luo, Jian, et al.
Publicado: (2016)

The Selectivity for Tumor Cells of Nuclear-Directed Cytotoxic RNases Is Mediated by the Nuclear/Cytoplasmic Distribution of p27(KIP1)
por: García-Galindo, Glòria, et al.
Publicado: (2021)

Status of p53 and p27(KIP1) in Iranian Patients With Oral Squamous Cell Carcinoma
por: Etemad-Moghadam, Shahroo, et al.
Publicado: (2015)

Inability to phosphorylate Y88 of p27(Kip1) enforces reduced p27 protein levels and accelerates leukemia progression
por: Jäkel, Heidelinde, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_iftrtvj77hon37gkr38b1ofdoq