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The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

The single nucleotide polymorphism (SNP) rs744373 in the bridging integrator-1 gene (BIN1) is a risk factor for Alzheimer’s disease (AD). In the brain, BIN1 is involved in endocytosis and sustaining cytoskeleton integrity. Post-mortem and in vitro studies suggest that BIN1-associated AD risk is medi...

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Detalles Bibliográficos
Autores principales: Franzmeier, Nicolai, Rubinski, Anna, Neitzel, Julia, Ewers, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467911/
https://www.ncbi.nlm.nih.gov/pubmed/30992433
http://dx.doi.org/10.1038/s41467-019-09564-5