An innate interaction between IL-18 and the propeptide that inactivates its precursor form

Uncontrolled secretion of mature interleukin (IL)-1β and IL-18 is responsible for severe autoinflammatory or autoimmune disorders and various allergic diseases. Here we report an intramolecular interaction between IL-18 and its propeptide, which is proteolytically removed from its precursor proIL-18...

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Detalles Bibliográficos
Autores principales: Tsutsumi, Naotaka, Yokota, Ayumi, Kimura, Takeshi, Kato, Zenichiro, Fukao, Toshiyuki, Shirakawa, Masahiro, Ohnishi, Hidenori, Tochio, Hidehito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467916/
https://www.ncbi.nlm.nih.gov/pubmed/30992532
http://dx.doi.org/10.1038/s41598-019-42661-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467916/
https://www.ncbi.nlm.nih.gov/pubmed/30992532
http://dx.doi.org/10.1038/s41598-019-42661-5

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