An innate interaction between IL-18 and the propeptide that inactivates its precursor form

Uncontrolled secretion of mature interleukin (IL)-1β and IL-18 is responsible for severe autoinflammatory or autoimmune disorders and various allergic diseases. Here we report an intramolecular interaction between IL-18 and its propeptide, which is proteolytically removed from its precursor proIL-18...

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Autores principales: Tsutsumi, Naotaka, Yokota, Ayumi, Kimura, Takeshi, Kato, Zenichiro, Fukao, Toshiyuki, Shirakawa, Masahiro, Ohnishi, Hidenori, Tochio, Hidehito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467916/
https://www.ncbi.nlm.nih.gov/pubmed/30992532
http://dx.doi.org/10.1038/s41598-019-42661-5
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author Tsutsumi, Naotaka
Yokota, Ayumi
Kimura, Takeshi
Kato, Zenichiro
Fukao, Toshiyuki
Shirakawa, Masahiro
Ohnishi, Hidenori
Tochio, Hidehito
author_facet Tsutsumi, Naotaka
Yokota, Ayumi
Kimura, Takeshi
Kato, Zenichiro
Fukao, Toshiyuki
Shirakawa, Masahiro
Ohnishi, Hidenori
Tochio, Hidehito
author_sort Tsutsumi, Naotaka
collection PubMed
description Uncontrolled secretion of mature interleukin (IL)-1β and IL-18 is responsible for severe autoinflammatory or autoimmune disorders and various allergic diseases. Here we report an intramolecular interaction between IL-18 and its propeptide, which is proteolytically removed from its precursor proIL-18 during maturation. The intramolecular interaction was recapitulated intermolecularly using recombinant propeptide. These results suggest the possibility of developing a novel class of peptide-based IL-18 inhibitors that could serve as therapeutic agents for IL-18-related inflammatory diseases.
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spelling pubmed-64679162019-04-23 An innate interaction between IL-18 and the propeptide that inactivates its precursor form Tsutsumi, Naotaka Yokota, Ayumi Kimura, Takeshi Kato, Zenichiro Fukao, Toshiyuki Shirakawa, Masahiro Ohnishi, Hidenori Tochio, Hidehito Sci Rep Article Uncontrolled secretion of mature interleukin (IL)-1β and IL-18 is responsible for severe autoinflammatory or autoimmune disorders and various allergic diseases. Here we report an intramolecular interaction between IL-18 and its propeptide, which is proteolytically removed from its precursor proIL-18 during maturation. The intramolecular interaction was recapitulated intermolecularly using recombinant propeptide. These results suggest the possibility of developing a novel class of peptide-based IL-18 inhibitors that could serve as therapeutic agents for IL-18-related inflammatory diseases. Nature Publishing Group UK 2019-04-16 /pmc/articles/PMC6467916/ /pubmed/30992532 http://dx.doi.org/10.1038/s41598-019-42661-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tsutsumi, Naotaka
Yokota, Ayumi
Kimura, Takeshi
Kato, Zenichiro
Fukao, Toshiyuki
Shirakawa, Masahiro
Ohnishi, Hidenori
Tochio, Hidehito
An innate interaction between IL-18 and the propeptide that inactivates its precursor form
title An innate interaction between IL-18 and the propeptide that inactivates its precursor form
title_full An innate interaction between IL-18 and the propeptide that inactivates its precursor form
title_fullStr An innate interaction between IL-18 and the propeptide that inactivates its precursor form
title_full_unstemmed An innate interaction between IL-18 and the propeptide that inactivates its precursor form
title_short An innate interaction between IL-18 and the propeptide that inactivates its precursor form
title_sort innate interaction between il-18 and the propeptide that inactivates its precursor form
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467916/
https://www.ncbi.nlm.nih.gov/pubmed/30992532
http://dx.doi.org/10.1038/s41598-019-42661-5
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