Polygenic prediction via Bayesian regression and continuous shrinkage priors

Polygenic risk scores (PRS) have shown promise in predicting human complex traits and diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior effect sizes of single nucleotide polymorphisms (SNPs) using genome-wide association summary statistics and an external linkage...

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Detalles Bibliográficos
Autores principales: Ge, Tian, Chen, Chia-Yen, Ni, Yang, Feng, Yen-Chen Anne, Smoller, Jordan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467998/
https://www.ncbi.nlm.nih.gov/pubmed/30992449
http://dx.doi.org/10.1038/s41467-019-09718-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467998/
https://www.ncbi.nlm.nih.gov/pubmed/30992449
http://dx.doi.org/10.1038/s41467-019-09718-5

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