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Analysis of tractable allosteric sites in G protein-coupled receptors

Allosteric modulation of G protein-coupled receptors represent a promising mechanism of pharmacological intervention. Dramatic developments witnessed in the structural biology of membrane proteins continue to reveal that the binding sites of allosteric modulators are widely distributed, including al...

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Detalles Bibliográficos
Autores principales: Wakefield, Amanda E., Mason, Jonathan S., Vajda, Sandor, Keserű, György M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467999/
https://www.ncbi.nlm.nih.gov/pubmed/30992500
http://dx.doi.org/10.1038/s41598-019-42618-8