Deficiency of the Fanconi anemia E2 ubiqitin conjugase UBE2T only partially abrogates Alu-mediated recombination in a new model of homology dependent recombination

The primary function of the UBE2T ubiquitin conjugase is in the monoubiquitination of the FANCI-FANCD2 heterodimer, a central step in the Fanconi anemia (FA) pathway. Genetic inactivation of UBE2T is responsible for the phenotypes of FANCT patients; however, a FANCT patient carrying a maternal dupli...

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Detalles Bibliográficos
Autores principales: Lewis, Todd W, Barthelemy, Joanna R, Virts, Elizabeth L, Kennedy, Felicia M, Gadgil, Rujuta Y, Wiek, Constanze, Linka, Rene M, Zhang, Feng, Andreassen, Paul R, Hanenberg, Helmut, Leffak, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468168/
https://www.ncbi.nlm.nih.gov/pubmed/30715513
http://dx.doi.org/10.1093/nar/gkz026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468168/
https://www.ncbi.nlm.nih.gov/pubmed/30715513
http://dx.doi.org/10.1093/nar/gkz026

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