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CRISPR-assisted multi-dimensional regulation for fine-tuning gene expression in Bacillus subtilis
Fine-tuning of gene expression is crucial for protein expression and pathway construction, but it still faces formidable challenges due to the hierarchical gene regulation at multiple levels in a context-dependent manner. In this study, we defined the optimal targeting windows for CRISPRa and CRISPR...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468239/ https://www.ncbi.nlm.nih.gov/pubmed/30767015 http://dx.doi.org/10.1093/nar/gkz072 |