The E3-ligases SCF(Ppa) and APC/C(Cdh1) co-operate to regulate CENP-A(CID) expression across the cell cycle

Centromere identity is determined by the specific deposition of CENP-A, a histone H3 variant localizing exclusively at centromeres. Increased CENP-A expression, which is a frequent event in cancer, causes mislocalization, ectopic kinetochore assembly and genomic instability. Proteolysis regulates CE...

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Detalles Bibliográficos
Autores principales: Moreno-Moreno, Olga, Torras-Llort, Mònica, Azorin, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468245/
https://www.ncbi.nlm.nih.gov/pubmed/30753559
http://dx.doi.org/10.1093/nar/gkz060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468245/
https://www.ncbi.nlm.nih.gov/pubmed/30753559
http://dx.doi.org/10.1093/nar/gkz060

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