The ATP-bound conformation of the Mre11–Rad50 complex is essential for Tel1/ATM activation

Activation of the checkpoint protein Tel1 requires the Mre11–Rad50–Xrs2 (MRX) complex, which recruits Tel1 at DNA double-strand breaks (DSBs) through direct interaction between Tel1 and Xrs2. However, in vitro Tel1 activation by MRX requires ATP binding to Rad50, suggesting a role also for the MR su...

Descripción completa

Detalles Bibliográficos
Autores principales: Cassani, Corinne, Vertemara, Jacopo, Bassani, Matteo, Marsella, Antonio, Tisi, Renata, Zampella, Giuseppe, Longhese, Maria Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468247/
https://www.ncbi.nlm.nih.gov/pubmed/30698745
http://dx.doi.org/10.1093/nar/gkz038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468247/
https://www.ncbi.nlm.nih.gov/pubmed/30698745
http://dx.doi.org/10.1093/nar/gkz038

Ejemplares similares