A high-throughput screen identifies small molecule modulators of alternative splicing by targeting RNA G-quadruplexes

RNA secondary structures have been increasingly recognized to play an important regulatory role in post-transcriptional gene regulation. We recently showed that RNA G-quadruplexes, which serve as cis-elements to recruit splicing factors, play a critical role in regulating alternative splicing during...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Harvey, Samuel E, Cheng, Chonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468248/
https://www.ncbi.nlm.nih.gov/pubmed/30698802
http://dx.doi.org/10.1093/nar/gkz036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468248/
https://www.ncbi.nlm.nih.gov/pubmed/30698802
http://dx.doi.org/10.1093/nar/gkz036

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