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A high-throughput screen identifies small molecule modulators of alternative splicing by targeting RNA G-quadruplexes
RNA secondary structures have been increasingly recognized to play an important regulatory role in post-transcriptional gene regulation. We recently showed that RNA G-quadruplexes, which serve as cis-elements to recruit splicing factors, play a critical role in regulating alternative splicing during...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468248/ https://www.ncbi.nlm.nih.gov/pubmed/30698802 http://dx.doi.org/10.1093/nar/gkz036 |