Deriving Ligand Orientation in Weak Protein–Ligand Complexes by DEEP‐STD NMR Spectroscopy in the Absence of Protein Chemical‐Shift Assignment

Differential epitope mapping saturation transfer difference (DEEP‐STD) NMR spectroscopy is a recently developed powerful approach for elucidating the structure and pharmacophore of weak protein–ligand interactions, as it reports key information on the orientation of the ligand and the architecture o...

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Detalles Bibliográficos
Autores principales: Nepravishta, Ridvan, Walpole, Samuel, Tailford, Louise, Juge, Nathalie, Angulo, Jesus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468252/
https://www.ncbi.nlm.nih.gov/pubmed/30379391
http://dx.doi.org/10.1002/cbic.201800568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468252/
https://www.ncbi.nlm.nih.gov/pubmed/30379391
http://dx.doi.org/10.1002/cbic.201800568

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