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ROS Scavenger, Ebselen, Has No Preventive Effect in New Hearing Loss Model Using a Cholesterol-Chelating Agent

BACKGROUND AND OBJECTIVES: The antioxidant ebselen will be able to limit or prevent the ototoxicity arising from 2-hydroxypropyl-β-cyclodextrin (HPβCD). Niemann-Pick Type C (NPC) disease is a disorder of lysosomal storage manifested in sphingolipidosis. Recently, it was noted that experimental use o...

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Detalles Bibliográficos
Autores principales: Lee, Min Young, Kabara, Lisa L., Swiderski, Donald L., Raphael, Yehoash, Duncan, R. Keith, Kim, Young Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Audiological Society and Korean Otological Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468279/
https://www.ncbi.nlm.nih.gov/pubmed/30727719
http://dx.doi.org/10.7874/jao.2018.00255