Fluorescently-labelled CPD and 6-4PP photolyases: new tools for live-cell DNA damage quantification and laser-assisted repair

UV light induces cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone (6-4) photoproducts (6-4PPs), which can result in carcinogenesis and aging, if not properly repaired by nucleotide excision repair (NER). Assays to determine DNA damage load and repair rates are invaluable tools for fund...

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Detalles Bibliográficos
Autores principales: Steurer, Barbara, Turkyilmaz, Yasemin, van Toorn, Marvin, van Leeuwen, Wessel, Escudero-Ferruz, Paula, Marteijn, Jurgen A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468286/
https://www.ncbi.nlm.nih.gov/pubmed/30698791
http://dx.doi.org/10.1093/nar/gkz035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468286/
https://www.ncbi.nlm.nih.gov/pubmed/30698791
http://dx.doi.org/10.1093/nar/gkz035

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