Set1-catalyzed H3K4 trimethylation antagonizes the HIR/Asf1/Rtt106 repressor complex to promote histone gene expression and chronological life span

Aging is the main risk factor for many prevalent diseases. However, the molecular mechanisms regulating aging at the cellular level are largely unknown. Using single cell yeast as a model organism, we found that reducing yeast histone proteins accelerates chronological aging and increasing histone s...

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Detalles Bibliográficos
Autores principales: Mei, Qianyun, Xu, Chen, Gogol, Madelaine, Tang, Jie, Chen, Wanping, Yu, Xilan, Workman, Jerry L, Li, Shanshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468302/
https://www.ncbi.nlm.nih.gov/pubmed/30759223
http://dx.doi.org/10.1093/nar/gkz101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468302/
https://www.ncbi.nlm.nih.gov/pubmed/30759223
http://dx.doi.org/10.1093/nar/gkz101

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