p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX

The disordered p53 transactivation domain (p53TAD) contains specific levels of transient helical secondary structure that are necessary for its binding to the negative regulators, mouse double minute 2 (Mdm2) and MdmX. The interactions of p53 with Mdm2 and MdmX are also modulated by posttranslationa...

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Detalles Bibliográficos
Autores principales: Levy, Robin, Gregory, Emily, Borcherds, Wade, Daughdrill, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468375/
https://www.ncbi.nlm.nih.gov/pubmed/30832340
http://dx.doi.org/10.3390/biom9030083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468375/
https://www.ncbi.nlm.nih.gov/pubmed/30832340
http://dx.doi.org/10.3390/biom9030083

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