ATG-18 and EPG-6 are Both Required for Autophagy but Differentially Contribute to Lifespan Control in Caenorhabditis elegans

During macroautophagy, the human WIPI (WD-repeat protein interacting with phosphoinositides) proteins (WIPI1–4) function as phosphatidylinositol 3-phosphate effectors at the nascent autophagosome. Likewise, the two WIPI homologues in Caenorhabditis elegans, ATG-18 and EPG-6, play important roles in...

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Detalles Bibliográficos
Autores principales: Takacs, Zsuzsanna, Sporbeck, Katharina, Stoeckle, Jennifer, Prado Carvajal, Maria Jhaneth, Grimmel, Mona, Proikas-Cezanne, Tassula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468378/
https://www.ncbi.nlm.nih.gov/pubmed/30871075
http://dx.doi.org/10.3390/cells8030236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468378/
https://www.ncbi.nlm.nih.gov/pubmed/30871075
http://dx.doi.org/10.3390/cells8030236

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