Anatomic Origin of Osteochondrogenic Progenitors Impacts Sensitivity to EWS-FLI1-Induced Transformation

Ewing sarcomas predominantly arise in pelvic and stylopod bones (i.e., femur and humerus), likely as a consequence of EWS-FLI1 oncogene-induced transformation of mesenchymal stem/progenitor cells (MSCs). MSCs located in the embryonic superficial zone cells (eSZ) of limbs express anatomically distinc...

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Detalles Bibliográficos
Autores principales: Pfaltzgraff, Elise R., Apfelbaum, April, Kassa, Andrew P., Song, Jane Y., Jiang, Wei, Suhan, Tahra K., Wellik, Deneen M., Lawlor, Elizabeth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468467/
https://www.ncbi.nlm.nih.gov/pubmed/30845695
http://dx.doi.org/10.3390/cancers11030313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468467/
https://www.ncbi.nlm.nih.gov/pubmed/30845695
http://dx.doi.org/10.3390/cancers11030313

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