GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells toward Breast Tumor Progression

The FGF2/FGFR1 paracrine loop is involved in the cross-talk between breast cancer cells and components of the tumor stroma as cancer-associated fibroblasts (CAFs). By quantitative PCR (qPCR), western blot, immunofluorescence analysis, ELISA and ChIP assays, we demonstrated that 17β-estradiol (E2) an...

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Detalles Bibliográficos
Autores principales: Santolla, Maria Francesca, Vivacqua, Adele, Lappano, Rosamaria, Rigiracciolo, Damiano Cosimo, Cirillo, Francesca, Galli, Giulia Raffaella, Talia, Marianna, Brunetti, Giuseppe, Miglietta, Anna Maria, Belfiore, Antonino, Maggiolini, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468560/
https://www.ncbi.nlm.nih.gov/pubmed/30866584
http://dx.doi.org/10.3390/cells8030223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468560/
https://www.ncbi.nlm.nih.gov/pubmed/30866584
http://dx.doi.org/10.3390/cells8030223

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