Therapeutic Targeting of Stat3 Using Lipopolyplex Nanoparticle-Formulated siRNA in a Syngeneic Orthotopic Mouse Glioma Model

Glioblastoma (GBM), WHO grade IV, is the most aggressive primary brain tumor in adults. The median survival time using standard therapy is only 12–15 months with a 5-year survival rate of around 5%. Thus, new and effective treatment modalities are of significant importance. Signal transducer and act...

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Detalles Bibliográficos
Autores principales: Linder, Benedikt, Weirauch, Ulrike, Ewe, Alexander, Uhmann, Anja, Seifert, Volker, Mittelbronn, Michel, Harter, Patrick N., Aigner, Achim, Kögel, Donat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468565/
https://www.ncbi.nlm.nih.gov/pubmed/30857197
http://dx.doi.org/10.3390/cancers11030333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468565/
https://www.ncbi.nlm.nih.gov/pubmed/30857197
http://dx.doi.org/10.3390/cancers11030333

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