Cargando…

Therapeutic Targeting of Stat3 Using Lipopolyplex Nanoparticle-Formulated siRNA in a Syngeneic Orthotopic Mouse Glioma Model

Glioblastoma (GBM), WHO grade IV, is the most aggressive primary brain tumor in adults. The median survival time using standard therapy is only 12–15 months with a 5-year survival rate of around 5%. Thus, new and effective treatment modalities are of significant importance. Signal transducer and act...

Descripción completa

Detalles Bibliográficos
Autores principales:	Linder, Benedikt, Weirauch, Ulrike, Ewe, Alexander, Uhmann, Anja, Seifert, Volker, Mittelbronn, Michel, Harter, Patrick N., Aigner, Achim, Kögel, Donat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468565/ https://www.ncbi.nlm.nih.gov/pubmed/30857197 http://dx.doi.org/10.3390/cancers11030333

Ejemplares similares

STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death
por: Remy, Janina, et al.
Publicado: (2022)

The Role of the Helper Lipid on the DNA Transfection Efficiency of Lipopolyplex Formulations
por: Du, Zixiu, et al.
Publicado: (2014)

Multicompartmental Lipopolyplex as Vehicle for Antigens and Genes Delivery in Vaccine Formulations
por: Sanmartín, Isaías, et al.
Publicado: (2021)

Sorafenib Sensitizes Glioma Cells to the BH3 Mimetic ABT-737 by Targeting MCL1 in a STAT3-Dependent Manner()()
por: Kiprianova, Irina, et al.
Publicado: (2015)

Therapeutic miR-506-3p Replacement in Pancreatic Carcinoma Leads to Multiple Effects including Autophagy, Apoptosis, Senescence, and Mitochondrial Alterations In Vitro and In Vivo
por: Borchardt, Hannes, et al.
Publicado: (2022)

Polymeric Nanoparticles Based on Tyrosine-Modified, Low Molecular Weight Polyethylenimines for siRNA Delivery
por: Ewe, Alexander, et al.
Publicado: (2019)

Highly efficient siRNA transfection in macrophages using apoptotic body-mimic Ca-PS lipopolyplex
por: Lai, Yueyang, et al.
Publicado: (2018)

Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown
por: Noske, Sandra, et al.
Publicado: (2020)

Autophagy in Cancer Cell Death
por: Linder, Benedikt, et al.
Publicado: (2019)

Lipopolyplex-Mediated Co-Delivery of Doxorubicin and FAK siRNA to Enhance Therapeutic Efficiency of Treating Colorectal Cancer
por: Debele, Tilahun Ayane, et al.
Publicado: (2023)

Development of lipopolyplexes for gene delivery: A comparison of the effects of differing modes of targeting peptide display on the structure and transfection activities of lipopolyplexes
por: Bofinger, Robin, et al.
Publicado: (2018)

Polyethyleneimine-Based Lipopolyplexes as Carriers in Anticancer Gene Therapies
por: Jerzykiewicz, Julia, et al.
Publicado: (2021)

Generation of a syngeneic orthotopic transplant model of prostate cancer metastasis
por: Ellis, Leigh, et al.
Publicado: (2014)

Establishment of a syngeneic orthotopic model of prostate cancer in immunocompetent rats
por: Suzuki, Shugo, et al.
Publicado: (2014)

Neutral Lipopolyplexes for In Vivo Delivery of Conventional and Replicative RNA Vaccine
por: Perche, Federico, et al.
Publicado: (2019)

Arsenic Trioxide and (−)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling
por: Linder, Benedikt, et al.
Publicado: (2019)

Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research
por: Evans, Jonathan P, et al.
Publicado: (2019)

A syngeneic MC38 orthotopic mouse model of colorectal cancer metastasis
por: Greenlee, Joshua D, et al.
Publicado: (2022)

Lipopolyplex for Therapeutic Gene Delivery and Its Application for the Treatment of Parkinson’s Disease
por: Chen, Wei, et al.
Publicado: (2016)

Role of liposome and peptide in the synergistic enhancement of transfection with a lipopolyplex vector
por: Munye, Mustafa M., et al.
Publicado: (2015)

The discovery and enhanced properties of trichain lipids in lipopolyplex gene delivery systems
por: Mohammadi, Atefeh, et al.
Publicado: (2019)

Antitumor Effects of N-Butylidenephthalide Encapsulated in Lipopolyplexs in Colorectal Cancer Cells
por: Chang, Kai-Fu, et al.
Publicado: (2020)

Modified fibrin hydrogel for sustained delivery of RNAi lipopolyplexes in skeletal muscle
por: Ngarande, Ellen, et al.
Publicado: (2022)

At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer
por: Kögel, Donat, et al.
Publicado: (2020)

Development of syngeneic murine cell lines for use in immunocompetent orthotopic lung cancer models
por: Nolan, Kyle, et al.
Publicado: (2020)

Protocol to assess the antitumor efficacy of an immunotherapeutic peptide in syngeneic orthotopic glioma mouse models
por: Chen, Apeng, et al.
Publicado: (2023)

Therapeutic siRNA: State-of-the-Art and Future Perspectives
por: Friedrich, Maik, et al.
Publicado: (2022)

Direct Comparison of Chol-siRNA Polyplexes and Chol-DsiRNA Polyplexes Targeting STAT3 in a Syngeneic Murine Model of TNBC
por: Ye, Zhen, et al.
Publicado: (2022)

Codelivery of mRNA with α-Galactosylceramide Using a New Lipopolyplex Formulation Induces a Strong Antitumor Response upon Intravenous Administration
por: Guevara, Maria L., et al.
Publicado: (2019)

Delivery Systems for the Direct Application of siRNAs to Induce RNA Interference (RNAi) In Vivo
por: Aigner, Achim
Publicado: (2006)

Applications of RNA interference: current state and prospects for siRNA-based strategies in vivo
por: Aigner, Achim
Publicado: (2007)

Cardiolipin-Based Lipopolyplex Platform for the Delivery of Diverse Nucleic Acids into Gram-Negative Bacteria
por: Perche, Federico, et al.
Publicado: (2019)

Delivery of pDNA to the Lung by Lipopolyplexes Using N-Lauroylsarcosine and Effect on the Pulmonary Fibrosis
por: Kurosaki, Tomoaki, et al.
Publicado: (2021)

Selective sodium iodide symporter (NIS) genetherapy of glioblastoma mediatedby EGFR-targeted lipopolyplexes
por: Spellerberg, Rebekka, et al.
Publicado: (2021)

Dexamethasone Treatment Limits Efficacy of Radiation, but Does Not Interfere With Glioma Cell Death Induced by Tumor Treating Fields
por: Linder, Benedikt, et al.
Publicado: (2021)

Curcumin, but not Prima-1, decreased tumor cell proliferation in the syngeneic murine orthotopic bladder tumor model
por: Watanabe, Fábio T., et al.
Publicado: (2011)

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
por: Anker, Jonathan F., et al.
Publicado: (2018)

Inhibition of PIM2 in liver cancer decreases tumor cell proliferation in vitro and in vivo primarily through the modulation of cell cycle progression
por: Kronschnabl, Pia, et al.
Publicado: (2019)

Glioblastoma Tissue Slice Tandem-Cultures for Quantitative Evaluation of Inhibitory Effects on Invasion and Growth
por: Sidorcenco, Vasile, et al.
Publicado: (2020)

Ovarian tumour growth is characterized by mevalonate pathway gene signature in an orthotopic, syngeneic model of epithelial ovarian cancer
por: Greenaway, James B., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kojsiilachktonfbf1dppp1tkk