Cargando…

CD44s Assembles Hyaluronan Coat on Filopodia and Extracellular Vesicles and Induces Tumorigenicity of MKN74 Gastric Carcinoma Cells

CD44 is a multifunctional adhesion molecule typically upregulated in malignant, inflamed and injured tissues. Due to its ability to bind multiple ligands present in the tumor microenvironment, it promotes multiple cellular functions related to tumorigenesis. Recent data has shown that CD44 and its p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Härkönen, Kai, Oikari, Sanna, Kyykallio, Heikki, Capra, Janne, Hakkola, Sini, Ketola, Kirsi, Thanigai Arasu, Uma, Daaboul, George, Malloy, Andrew, Oliveira, Carla, Jokelainen, Otto, Sironen, Reijo, Hartikainen, Jaana M., Rilla, Kirsi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468717/ https://www.ncbi.nlm.nih.gov/pubmed/30909497 http://dx.doi.org/10.3390/cells8030276

Ejemplares similares

The Density and Length of Filopodia Associate with the Activity of Hyaluronan Synthesis in Tumor Cells
por: Kyykallio, Heikki, et al.
Publicado: (2020)

MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration
por: Aaltonen, Niina, et al.
Publicado: (2022)

Hyaluronan Synthase 1: A Mysterious Enzyme with Unexpected Functions
por: Siiskonen, Hanna, et al.
Publicado: (2015)

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma
por: Nykopp, Timo K, et al.
Publicado: (2010)

Expression of Hyaluronan Synthases (HAS1–3) and Hyaluronidases (HYAL1–2) in Serous Ovarian Carcinomas: Inverse Correlation between HYAL1 and Hyaluronan Content
por: Nykopp, Timo K, et al.
Publicado: (2009)

Characterization of hyaluronan-coated extracellular vesicles in synovial fluid of patients with osteoarthritis and rheumatoid arthritis
por: Mustonen, Anne-Mari, et al.
Publicado: (2021)

A quick pipeline for the isolation of 3D cell culture‐derived extracellular vesicles
por: Kyykallio, Heikki, et al.
Publicado: (2022)

Tumor microenvironment and breast cancer survival: combined effects of breast fat, M2 macrophages and hyaluronan create a dismal prognosis
por: Tiainen, Satu, et al.
Publicado: (2019)

The prognostic and predictive role of the neutrophil-to-lymphocyte ratio and the monocyte-to-lymphocyte ratio in early breast cancer, especially in the HER2+ subtype
por: Tiainen, Satu, et al.
Publicado: (2020)

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells
por: Arasu, Uma Thanigai, et al.
Publicado: (2019)

Fatty Acid Fingerprints and Hyaluronic Acid in Extracellular Vesicles from Proliferating Human Fibroblast-like Synoviocytes
por: Mustonen, Anne-Mari, et al.
Publicado: (2022)

Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas
por: Valkonen, Mari, et al.
Publicado: (2018)

Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles
por: Lázaro-Ibáñez, Elisa, et al.
Publicado: (2017)

Counts of hyaluronic acid-containing extracellular vesicles decrease in naturally occurring equine osteoarthritis
por: Mustonen, Anne-Mari, et al.
Publicado: (2022)

Inverse expression of hyaluronidase 2 and hyaluronan synthases 1–3 is associated with reduced hyaluronan content in malignant cutaneous melanoma
por: Hanna, Siiskonen, et al.
Publicado: (2013)

Diverse plasma membrane protrusions act as platforms for extracellular vesicle shedding
por: Rilla, Kirsi
Publicado: (2021)

Isolation of Extracellular Vesicles From the Bronchoalveolar Lavage Fluid of Healthy and Asthmatic Horses
por: Höglund, Nina, et al.
Publicado: (2022)

Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles
por: Rilla, Kirsi, et al.
Publicado: (2015)

Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism
por: Matilainen, Johanna, et al.
Publicado: (2020)

The Impact of Hyaluronan on Tumor Progression in Cutaneous Melanoma
por: Takabe, Piia, et al.
Publicado: (2022)

Decreased expression of hyaluronan synthase 1 and 2 associates with poor prognosis in cutaneous melanoma
por: Poukka, Mari, et al.
Publicado: (2016)

Chemical Biology Drug Sensitivity Screen Identifies Sunitinib as Synergistic Agent with Disulfiram in Prostate Cancer Cells
por: Ketola, Kirsi, et al.
Publicado: (2012)

Molecular and Functional Links between Neurodevelopmental Processes and Treatment-Induced Neuroendocrine Plasticity in Prostate Cancer Progression
por: Kaarijärvi, Roosa, et al.
Publicado: (2021)

The impact of insulin on chemotherapeutic sensitivity to 5-fluorouracil in gastric cancer cell lines SGC7901, MKN45 and MKN28
por: Wei, Zhao, et al.
Publicado: (2015)

Ethanol extracts of Allium sp. regulate cyclooxygenase-2 and E-cadherin expression in gastric cancer MKN74 cell line and enhance doxorubicin toxicity
por: Korga, Agnieszka, et al.
Publicado: (2019)

Filopodia motor ahead
por: Leslie, Mitch
Publicado: (2007)

Viruses infect filopodia
por: LeBrasseur, Nicole
Publicado: (2007)

The Finer Points of Filopodia
por: Lundquist, Erik A.
Publicado: (2009)

Metformin decreases hyaluronan synthesis by vascular smooth muscle cells
por: Sainio, Annele, et al.
Publicado: (2020)

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells
por: Viiri, Johanna, et al.
Publicado: (2013)

Large zenith angle observations of Mkn 421 with H.E.S.S
por: Horns, D
Publicado: (2005)

Effects of growth factor deprivation on MKN-45 spheroid cells
por: TÜRKSOY TERZİOĞLU, Özlem, et al.
Publicado: (2023)

Nuclear expression of Snail1 in borderline and malignant epithelial ovarian tumours is associated with tumour progression
por: Tuhkanen, Hanna, et al.
Publicado: (2009)

High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation
por: Sokka, Miiko, et al.
Publicado: (2015)

Urge to merge erects filopodia
por: Dove, Alan W.
Publicado: (2003)

Bending membrane to form filopodia
por: Williams, Ruth
Publicado: (2007)

Islands of Conformational Stability for Filopodia
por: Daniels, D. Robert, et al.
Publicado: (2013)

The role of filopodia in the recognition of nanotopographies
por: Albuschies, Jörg, et al.
Publicado: (2013)

Tissue guidance without filopodia
por: Wacker, Andrin, et al.
Publicado: (2014)

Evaluating the Magnolol Anticancer Potential in MKN-45 Gastric Cancer Cells
por: Naghashpour, Mahsa, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j3kef1mkklrqefth4i66mp1nci