Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo

Dysfunction of autophagy and disturbed protein homeostasis are linked to the pathogenesis of human neurodegenerative diseases and the modulation of autophagy as the protein clearance process has become one key pharmacological target. Due to the role of sigma-1 receptors (Sig-1R) in learning and memo...

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Detalles Bibliográficos
Autores principales: Christ, Maximilian G., Huesmann, Heike, Nagel, Heike, Kern, Andreas, Behl, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468724/
https://www.ncbi.nlm.nih.gov/pubmed/30832324
http://dx.doi.org/10.3390/cells8030211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468724/
https://www.ncbi.nlm.nih.gov/pubmed/30832324
http://dx.doi.org/10.3390/cells8030211

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