The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis

Currently, there are no effective therapies for patients with triple-negative breast cancer (TNBC), an aggressive and highly metastatic disease. Activation of eukaryotic initiation factor 4E (eIF4E) by mitogen-activated protein kinase (MAPK)-interacting kinases 1 and 2 (Mnk1/2) play a critical role...

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Detalles Bibliográficos
Autores principales: Ramalingam, Senthilmurugan, Ramamurthy, Vidya P., Gediya, Lalji K., Murigi, Francis N., Purushottamachar, Puranik, Huang, Weiliang, Choi, Eun Yong, Zhang, Yuji, Vasaitis, Tadas S, Kane, Maureen A., Lapidus, Rena G., Njar, Vincent C. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468747/
https://www.ncbi.nlm.nih.gov/pubmed/30832411
http://dx.doi.org/10.3390/cancers11030299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468747/
https://www.ncbi.nlm.nih.gov/pubmed/30832411
http://dx.doi.org/10.3390/cancers11030299

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