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The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis
Currently, there are no effective therapies for patients with triple-negative breast cancer (TNBC), an aggressive and highly metastatic disease. Activation of eukaryotic initiation factor 4E (eIF4E) by mitogen-activated protein kinase (MAPK)-interacting kinases 1 and 2 (Mnk1/2) play a critical role...
Autores principales: | Ramalingam, Senthilmurugan, Ramamurthy, Vidya P., Gediya, Lalji K., Murigi, Francis N., Purushottamachar, Puranik, Huang, Weiliang, Choi, Eun Yong, Zhang, Yuji, Vasaitis, Tadas S, Kane, Maureen A., Lapidus, Rena G., Njar, Vincent C. O. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468747/ https://www.ncbi.nlm.nih.gov/pubmed/30832411 http://dx.doi.org/10.3390/cancers11030299 |
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