Dual Role of the Alternative Reading Frame ARF Protein in Cancer

The CDKN2a/ARF locus expresses two partially overlapping transcripts that encode two distinct proteins, namely p14ARF (p19Arf in mouse) and p16INK4a, which present no sequence identity. Initial data obtained in mice showed that both proteins are potent tumor suppressors. In line with a tumor-suppres...

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Detalles Bibliográficos
Autores principales: Fontana, Rosa, Ranieri, Michela, La Mantia, Girolama, Vivo, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468759/
https://www.ncbi.nlm.nih.gov/pubmed/30836703
http://dx.doi.org/10.3390/biom9030087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468759/
https://www.ncbi.nlm.nih.gov/pubmed/30836703
http://dx.doi.org/10.3390/biom9030087

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