Exploring the Frequency of Homologous Recombination DNA Repair Dysfunction in Multiple Cancer Types

Dysfunctional homologous recombination DNA repair (HRR), frequently due to BRCA mutations, is a determinant of sensitivity to platinum chemotherapy and poly(ADP-ribose) polymerase inhibitors (PARPi). In cultures of ovarian cancer cells, we have previously shown that HRR function, based upon RAD51 fo...

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Detalles Bibliográficos
Autores principales: Gentles, Lucy, Goranov, Bojidar, Matheson, Elizabeth, Herriott, Ashleigh, Kaufmann, Angelika, Hall, Sally, Mukhopadhyay, Asima, Drew, Yvette, Curtin, Nicola J., O’Donnell, Rachel L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468835/
https://www.ncbi.nlm.nih.gov/pubmed/30871186
http://dx.doi.org/10.3390/cancers11030354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468835/
https://www.ncbi.nlm.nih.gov/pubmed/30871186
http://dx.doi.org/10.3390/cancers11030354

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