Delta-Tocotrienol Modulates Glutamine Dependence by Inhibiting ASCT2 and LAT1 Transporters in Non-Small Cell Lung Cancer (NSCLC) Cells: A Metabolomic Approach

The growth and development of non-small cell lung cancer (NSCLC) primarily depends on glutamine. Both glutamine and essential amino acids (EAAs) have been reported to upregulate mTOR in NSCLC, which is a bioenergetics sensor involved in the regulation of cell growth, cell survival, and protein synth...

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Detalles Bibliográficos
Autores principales: Rajasinghe, Lichchavi Dhananjaya, Hutchings, Melanie, Gupta, Smiti Vaid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468853/
https://www.ncbi.nlm.nih.gov/pubmed/30871192
http://dx.doi.org/10.3390/metabo9030050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468853/
https://www.ncbi.nlm.nih.gov/pubmed/30871192
http://dx.doi.org/10.3390/metabo9030050

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