Molecular Docking and Dynamics Simulation Studies Predict Munc18b as a Target of Mycolactone: A Plausible Mechanism for Granule Exocytosis Impairment in Buruli Ulcer Pathogenesis

Ulcers due to infections with Mycobacterium ulcerans are characterized by complete lack of wound healing processes, painless, an underlying bed of host dead cells and undermined edges due to necrosis. Mycolactone, a macrolide produced by the mycobacterium, is believed to be the toxin responsible. Of...

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Detalles Bibliográficos
Autores principales: Kwofie, Samuel K., Dankwa, Bismark, Enninful, Kweku S., Adobor, Courage, Broni, Emmanuel, Ntiamoah, Alfred, Wilson, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468854/
https://www.ncbi.nlm.nih.gov/pubmed/30934618
http://dx.doi.org/10.3390/toxins11030181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468854/
https://www.ncbi.nlm.nih.gov/pubmed/30934618
http://dx.doi.org/10.3390/toxins11030181

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