CAFs and TGF-β Signaling Activation by Mast Cells Contribute to Resistance to Gemcitabine/Nabpaclitaxel in Pancreatic Cancer

Tumor–stroma interactions are of key importance for pancreatic ductal adenocarcinoma (PDAC) progression. Our aim was to investigate whether cancer associated fibroblasts (CAFs) and mast cells (MC) affected the sensitivity of PDAC cells to gemcitabine/nabpaclitaxel (GEM/NAB). For this purpose, the co...

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Detalles Bibliográficos
Autores principales: Porcelli, Letizia, Iacobazzi, Rosa Maria, Di Fonte, Roberta, Serratì, Simona, Intini, Angelica, Solimando, Antonio Giovanni, Brunetti, Oronzo, Calabrese, Angela, Leonetti, Francesco, Azzariti, Amalia, Silvestris, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468868/
https://www.ncbi.nlm.nih.gov/pubmed/30866547
http://dx.doi.org/10.3390/cancers11030330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468868/
https://www.ncbi.nlm.nih.gov/pubmed/30866547
http://dx.doi.org/10.3390/cancers11030330

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