Uniform Widespread Nuclear Phosphorylation of Histone H2AX Is an Indicator of Lethal DNA Replication Stress

Phosphorylated histone H2AX (γ-H2AX), a central player in the DNA damage response (DDR), serves as a biomarker of DNA double-strand break repair. Although DNA damage is generally visualized by the formation of γ-H2AX foci in injured nuclei, it is unclear whether the widespread uniform nuclear γ-H2AX...

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Detalles Bibliográficos
Autores principales: Moeglin, Eric, Desplancq, Dominique, Conic, Sascha, Oulad-Abdelghani, Mustapha, Stoessel, Audrey, Chiper, Manuela, Vigneron, Marc, Didier, Pascal, Tora, Laszlo, Weiss, Etienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468890/
https://www.ncbi.nlm.nih.gov/pubmed/30871194
http://dx.doi.org/10.3390/cancers11030355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468890/
https://www.ncbi.nlm.nih.gov/pubmed/30871194
http://dx.doi.org/10.3390/cancers11030355

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