The Immunogenicity in Mice of HCV Core Delivered as DNA Is Modulated by Its Capacity to Induce Oxidative Stress and Oxidative Stress Response

HCV core is an attractive HCV vaccine target, however, clinical or preclinical trials of core-based vaccines showed little success. We aimed to delineate what restricts its immunogenicity and improve immunogenic performance in mice. We designed plasmids encoding full-length HCV 1b core and its varia...

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Detalles Bibliográficos
Autores principales: Jansons, Juris, Sominskaya, Irina, Petrakova, Natalia, Starodubova, Elizaveta S., Smirnova, Olga A., Alekseeva, Ekaterina, Bruvere, Ruta, Eliseeva, Olesja, Skrastina, Dace, Kashuba, Elena, Mihailova, Marija, Kochetkov, Sergey N., Ivanov, Alexander V., Isaguliants, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468923/
https://www.ncbi.nlm.nih.gov/pubmed/30823485
http://dx.doi.org/10.3390/cells8030208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468923/
https://www.ncbi.nlm.nih.gov/pubmed/30823485
http://dx.doi.org/10.3390/cells8030208

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