Osteosarcoma Therapy: Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation (Adv. Sci. 8/2019)

In article number 1801233, Jianxun Ding, Yingqi Hua, Zhengdong Cai, and co‐workers report a combination strategy for improving the efficacy of fullerene C60 nanocrystals in anti‐osteosarcoma therapy. Inhibition of CaMKIIα activity by KN‐93 promotes excessive autophagosome accumulation and autophagic...

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Detalles Bibliográficos
Autores principales: Xu, Jing, Wang, Hongsheng, Hu, Yi, Zhang, Yu Shrike, Wen, Longping, Yin, Fei, Wang, Zhuoying, Zhang, Yingchao, Li, Suoyuan, Miao, Yanyan, Lin, Binhui, Zuo, Dongqing, Wang, Gangyang, Mao, Min, Zhang, Tao, Ding, Jianxun, Hua, Yingqi, Cai, Zhengdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468958/
http://dx.doi.org/10.1002/advs.201970051
Descripción
Sumario:In article number 1801233, Jianxun Ding, Yingqi Hua, Zhengdong Cai, and co‐workers report a combination strategy for improving the efficacy of fullerene C60 nanocrystals in anti‐osteosarcoma therapy. Inhibition of CaMKIIα activity by KN‐93 promotes excessive autophagosome accumulation and autophagic degradation blockage through lysosomal dysfunction induction and further upregulates the anti‐osteosarcoma effect of fullerene C60 nanocrystals. [Image: see text]

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