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Osteosarcoma Therapy: Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation (Adv. Sci. 8/2019)
In article number 1801233, Jianxun Ding, Yingqi Hua, Zhengdong Cai, and co‐workers report a combination strategy for improving the efficacy of fullerene C60 nanocrystals in anti‐osteosarcoma therapy. Inhibition of CaMKIIα activity by KN‐93 promotes excessive autophagosome accumulation and autophagic...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468958/ http://dx.doi.org/10.1002/advs.201970051 |
| _version_ | 1783411547567030272 |
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| author | Xu, Jing Wang, Hongsheng Hu, Yi Zhang, Yu Shrike Wen, Longping Yin, Fei Wang, Zhuoying Zhang, Yingchao Li, Suoyuan Miao, Yanyan Lin, Binhui Zuo, Dongqing Wang, Gangyang Mao, Min Zhang, Tao Ding, Jianxun Hua, Yingqi Cai, Zhengdong |
| author_facet | Xu, Jing Wang, Hongsheng Hu, Yi Zhang, Yu Shrike Wen, Longping Yin, Fei Wang, Zhuoying Zhang, Yingchao Li, Suoyuan Miao, Yanyan Lin, Binhui Zuo, Dongqing Wang, Gangyang Mao, Min Zhang, Tao Ding, Jianxun Hua, Yingqi Cai, Zhengdong |
| author_sort | Xu, Jing |
| collection | PubMed |
| description | In article number 1801233, Jianxun Ding, Yingqi Hua, Zhengdong Cai, and co‐workers report a combination strategy for improving the efficacy of fullerene C60 nanocrystals in anti‐osteosarcoma therapy. Inhibition of CaMKIIα activity by KN‐93 promotes excessive autophagosome accumulation and autophagic degradation blockage through lysosomal dysfunction induction and further upregulates the anti‐osteosarcoma effect of fullerene C60 nanocrystals. [Image: see text] |
| format | Online Article Text |
| id | pubmed-6468958 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-64689582019-04-23 Osteosarcoma Therapy: Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation (Adv. Sci. 8/2019) Xu, Jing Wang, Hongsheng Hu, Yi Zhang, Yu Shrike Wen, Longping Yin, Fei Wang, Zhuoying Zhang, Yingchao Li, Suoyuan Miao, Yanyan Lin, Binhui Zuo, Dongqing Wang, Gangyang Mao, Min Zhang, Tao Ding, Jianxun Hua, Yingqi Cai, Zhengdong Adv Sci (Weinh) Back Cover In article number 1801233, Jianxun Ding, Yingqi Hua, Zhengdong Cai, and co‐workers report a combination strategy for improving the efficacy of fullerene C60 nanocrystals in anti‐osteosarcoma therapy. Inhibition of CaMKIIα activity by KN‐93 promotes excessive autophagosome accumulation and autophagic degradation blockage through lysosomal dysfunction induction and further upregulates the anti‐osteosarcoma effect of fullerene C60 nanocrystals. [Image: see text] John Wiley and Sons Inc. 2019-04-17 /pmc/articles/PMC6468958/ http://dx.doi.org/10.1002/advs.201970051 Text en © 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Back Cover Xu, Jing Wang, Hongsheng Hu, Yi Zhang, Yu Shrike Wen, Longping Yin, Fei Wang, Zhuoying Zhang, Yingchao Li, Suoyuan Miao, Yanyan Lin, Binhui Zuo, Dongqing Wang, Gangyang Mao, Min Zhang, Tao Ding, Jianxun Hua, Yingqi Cai, Zhengdong Osteosarcoma Therapy: Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation (Adv. Sci. 8/2019) |
| title | Osteosarcoma Therapy: Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation (Adv. Sci. 8/2019) |
| title_full | Osteosarcoma Therapy: Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation (Adv. Sci. 8/2019) |
| title_fullStr | Osteosarcoma Therapy: Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation (Adv. Sci. 8/2019) |
| title_full_unstemmed | Osteosarcoma Therapy: Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation (Adv. Sci. 8/2019) |
| title_short | Osteosarcoma Therapy: Inhibition of CaMKIIα Activity Enhances Antitumor Effect of Fullerene C60 Nanocrystals by Suppression of Autophagic Degradation (Adv. Sci. 8/2019) |
| title_sort | osteosarcoma therapy: inhibition of camkiiα activity enhances antitumor effect of fullerene c60 nanocrystals by suppression of autophagic degradation (adv. sci. 8/2019) |
| topic | Back Cover |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468958/ http://dx.doi.org/10.1002/advs.201970051 |
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