WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP

WP1130, a partially selective deubiquitinases (DUB) inhibitor, inhibits the deubiquitinating activities of USP5, USP9X, USP14, USP37, and UCHL1. In this study, we investigate whether WP1130 exerts sensitizing effect on TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human renal ca...

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Detalles Bibliográficos
Autores principales: Kim, Seok, Woo, Seon Min, Min, Kyoung-jin, Seo, Seung Un, Lee, Tae-Jin, Kubatka, Peter, Kim, Dong Eun, Kwon, Taeg Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469024/
https://www.ncbi.nlm.nih.gov/pubmed/30862047
http://dx.doi.org/10.3390/cancers11030344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469024/
https://www.ncbi.nlm.nih.gov/pubmed/30862047
http://dx.doi.org/10.3390/cancers11030344

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