Cargando…

WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP

WP1130, a partially selective deubiquitinases (DUB) inhibitor, inhibits the deubiquitinating activities of USP5, USP9X, USP14, USP37, and UCHL1. In this study, we investigate whether WP1130 exerts sensitizing effect on TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human renal ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Seok, Woo, Seon Min, Min, Kyoung-jin, Seo, Seung Un, Lee, Tae-Jin, Kubatka, Peter, Kim, Dong Eun, Kwon, Taeg Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469024/ https://www.ncbi.nlm.nih.gov/pubmed/30862047 http://dx.doi.org/10.3390/cancers11030344

Ejemplares similares

Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP
por: Jeon, Mi-Yeon, et al.
Publicado: (2018)

Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma
por: Woo, Seon Min, et al.
Publicado: (2019)

Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation
por: Woo, Seon Min, et al.
Publicado: (2019)

Volasertib Enhances Sensitivity to TRAIL in Renal Carcinoma Caki Cells through Downregulation of c-FLIP Expression
por: Jeon, Mi-Yeon, et al.
Publicado: (2017)

Dexamethasone Inhibits TRAIL-Induced Apoptosis through c-FLIP(L) Upregulation and DR5 Downregulation by GSK3β Activation in Cancer Cells
por: Jeon, Mi-Yeon, et al.
Publicado: (2020)

Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
por: Kim, Seok, et al.
Publicado: (2018)

WP1130 reveals USP24 as a novel target in T-cell acute lymphoblastic leukemia
por: Luo, Hao, et al.
Publicado: (2019)

Inhibition of USP2 Enhances TRAIL-Mediated Cancer Cell Death through Downregulation of Survivin
por: Lee, Tak Gyeom, et al.
Publicado: (2023)

Magnolol Enhances the Therapeutic Effects of TRAIL through DR5 Upregulation and Downregulation of c-FLIP and Mcl-1 Proteins in Cancer Cells
por: Woo, Seon Min, et al.
Publicado: (2020)

Tubeimoside-1 Enhances TRAIL-Induced Apoptotic Cell Death through STAMBPL1-Mediated c-FLIP Downregulation
por: Song, So Rae, et al.
Publicado: (2023)

Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells
por: Yun, Jeong Mi, et al.
Publicado: (2018)

BIX-01294 sensitizes renal cancer Caki cells to TRAIL-induced apoptosis through downregulation of survivin expression and upregulation of DR5 expression
por: Woo, Seon Min, et al.
Publicado: (2018)

Hispidulin Enhances TRAIL-Mediated Apoptosis via CaMKKβ/AMPK/USP51 Axis-Mediated Bim Stabilization
por: Woo, Seon Min, et al.
Publicado: (2019)

Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway
por: Shahriyar, Sk Abrar, et al.
Publicado: (2020)

Cepharanthine Enhances TRAIL-Mediated Apoptosis Through STAMBPL1-Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells
por: Shahriyar, Sk Abrar, et al.
Publicado: (2018)

YM155 sensitizes TRAIL-induced apoptosis through cathepsin S-dependent down-regulation of Mcl-1 and NF-κB-mediated down-regulation of c-FLIP expression in human renal carcinoma Caki cells
por: Woo, Seon Min, et al.
Publicado: (2016)

Inhibition of c-FLIP(L) expression by miRNA-708 increases the sensitivity of renal cancer cells to anti-cancer drugs
por: Kim, Eun-Ae, et al.
Publicado: (2016)

Thioridazine enhances sensitivity to carboplatin in human head and neck cancer cells through downregulation of c-FLIP and Mcl-1 expression
por: Seo, Seung Un, et al.
Publicado: (2017)

WP1130 attenuates cisplatin resistance by decreasing P53 expression in non–small cell lung carcinomas
por: Wang, Xiang, et al.
Publicado: (2017)

Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5
por: Woo, Seon Min, et al.
Publicado: (2022)

Inhibition of Drp1 Sensitizes Cancer Cells to Cisplatin-Induced Apoptosis through Transcriptional Inhibition of c-FLIP Expression
por: Woo, Seon Min, et al.
Publicado: (2020)

NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin
por: Seo, Seung Un, et al.
Publicado: (2017)

FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells
por: Woo, Seon Min, et al.
Publicado: (2015)

Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin
por: Woo, Seon Min, et al.
Publicado: (2017)

USP41 Enhances Epithelial–Mesenchymal Transition of Breast Cancer Cells through Snail Stabilization
por: Yoon, Ji-Yun, et al.
Publicado: (2023)

Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells
por: Park, Eun Jung, et al.
Publicado: (2016)

Cathepsin K inhibition-induced mitochondrial ROS enhances sensitivity of cancer cells to anti-cancer drugs through USP27x-mediated Bim protein stabilization
por: Seo, Seung Un, et al.
Publicado: (2019)

Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells
por: Jung, Kyong-Jin, et al.
Publicado: (2015)

Lucanthone, Autophagy Inhibitor, Enhances the Apoptotic Effects of TRAIL through miR-216a-5p-Mediated DR5 Upregulation and DUB3-Mediated Mcl-1 Downregulation
por: Yoon, Ji Yun, et al.
Publicado: (2021)

Eupafolin enhances TRAIL-mediated apoptosis through cathepsin S-induced down-regulation of Mcl-1 expression and AMPK-mediated Bim up-regulation in renal carcinoma Caki cells
por: Han, Min Ae, et al.
Publicado: (2016)

Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization
por: Wu, Kaixin, et al.
Publicado: (2021)

Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress
por: Seo, Seung Un, et al.
Publicado: (2018)

Itch and autophagy-mediated NF-κB activation contributes to inhibition of cathepsin D-induced sensitizing effect on anticancer drugs
por: Seo, Seung Un, et al.
Publicado: (2022)

The coffee diterpene kahweol enhances sensitivity to sorafenib in human renal carcinoma Caki cells through down-regulation of Mcl-1 and c-FLIP expression
por: Min, Kyoung-Jin, et al.
Publicado: (2017)

View of the IBM 1130 computer
por: CERN PhotoLab
Publicado: (1968)

Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells
por: Han, Min Ae, et al.
Publicado: (2016)

E3 ubiquitin ligases and deubiquitinases as modulators of TRAIL-mediated extrinsic apoptotic signaling pathway
por: Woo, Seon Min, et al.
Publicado: (2019)

HSP70 Acetylation Prevents Combined mTORC1/2 Inhibitor and Curcumin Treatment-Induced Apoptosis
por: Seo, Seung Un, et al.
Publicado: (2018)

Programación del sistema IBM 1130
por: Huges, Joan Kirkby
Publicado: (1973)

mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy
por: Seo, Seung Un, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rdvr5tjfv4ih9npcdj7nj3i4rj