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Resetting the Stress System with a Mifepristone Challenge

Psychotic depression is characterized by elevated circulating cortisol, and high daily doses of the glucocorticoid/progesterone antagonist mifepristone for 1 week are required for significant improvement. Using a rodent model, we find that such high doses of mifepristone are needed because the antag...

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Detalles Bibliográficos
Autores principales: Dalm, Sergiu, Karssen, Adriaan M., Meijer, Onno C., Belanoff, Joseph K., de Kloet, E. Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469632/
https://www.ncbi.nlm.nih.gov/pubmed/30173378
http://dx.doi.org/10.1007/s10571-018-0614-5